Mr. Fister? I have to say, when I read that name it conjured up an entirely different image...
I can't say that I have a single favorite villain. I do have a few that I have a special fondness for:
1. The Goblin King: A former robotics engineer for DARPA who suffered a psychotic break after his wife and daughter were killed in a freak accident. Believing himself to be Alberich, the dwarf king from the Niebelungen (he suffers from pseudo-achondroplasia, a form of short-limbed dwarfism). Operating out of a number of secret lairs beneath the streets of Atom City (my primary campaign setting), he launches periodic attacks against the "surface world." He employs an army of robotic goblin and troll minions, piloting drill-nosed tank-like vehicles.
Just a goofy, fun villain.
2. The Hand: Immortal sorcerer who claims to have been the inspiration for the biblical story of Cain (of Cain and Abel fame), as well as the Tooth Fairy and the Sandman (he regularly murders children to steal their teeth and eyes to use as components for his spells). He is a powerful sorcerer (most of his spells involve summoning and controlling demons) and his right hand has been replaced by an enchanted Hand of Glory that grants him additional powers useful in carrying out his wicked schemes. Although his spells render him effectively immortal, they do not entirely protect him from the ravages of time, and his body is wracked by dozens of diseases and debilitating conditions.
He is a member of The Grotesquerie (a loose cabal of the most powerful & evil sorcerers and supernatural beings in my campaign world) and has several minions empowered by demons he has bound to their souls: Bone (who has invisible/immaterial skin and indestructible skeleton), Grinning Man (a demented strangler who can only be seen via peripheral vision; if looked at directly, he is invisible), Lepus (a super-strong, axe-wielding maniac who wears a bunny suit), and Freeshooter (a master marksman with enchanted bullets).
I just like this guy because he is probably the single most wicked character I have ever created, just pure evil.
3. Crowbar: Super-strong, invulnerable bruiser who wields a crowbar in combat. Muscle for hire for the local mobs.
Not sure why I like this guy so much. Might be a nostalgia thing, as he was my go-to NPC whenever I needed a strong guy thug to throw at my players back in the heyday of my gaming days. The players always groaned when he made an appearance, because they knew they were in for a fight.
4. Almost forgot: The Paranormal: A psychopharmacologist who developed potent psychic powers after a traumatic brain injury (he was shot in the forehead). He was recruited by The Hive, a terrorist group that used psychically powered agents, using their facilities to fund his experiments to develop a drug to further enhance his powers, until he went rogue after killing a dozen of their agents. He suffered periodic psychotic episodes as a result of his brain injury and drug experimentation.
He was fun to run because he was: a. powerful enough to take on a whole team of PCs single-handed (he had telepathic, force field, and energy blast powers), and because, thanks to his psychotic episodes, the PCs never knew who they would be facing, a cool-headed, utterly ruthless master planner, or a totally unhinged raging maniac.
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